RKDHAUGODA'S GENERAL THEORY OF VASCULITIS

Features of R.K. Dhaugoda’s
General Equation of Vasculitis
(R.K.Dhaugoda’s general theory of vasculitis)
 BY- DR. RAJ KUMAR DHAUGODA OF NEPAL,MBBS ,MD FAM.MED.


1. This R.K. Dhaugoda’s general equation of vasculitis helps to establish a new out look or view of a new scientific integrated concept of understanding and management of health and disease in a simple and accessible way.

2. This equation helps to decrease more than 80% of ICU mortality and morbidity, many chronic diseases viz, most of the vasculitis diseases, mental diseases, oncologic disease, by means preventions and curative ways.

3. This general equation of vasculitis is a universal weapon against most of the chronic, auto immune, degenerative diseases,psychiatric disorders which have not curative so far and curative weapon for many acute severe diseases, acute Asthma, ALI, ARDS, Severe sepsis, severe burn, Tetanus,AIDS AND MANY VIRAL DISEASES etc.

4. This new Equation will have brought a revolution in the field of health and disease, in terms of concept, pathogenesis, prevention, understanding and cost effective management of health and diseases. In our society, it will bring a great revolution in terms of cost effective, time constrain diseases management, change in economic and politics and the importance and practical application of dialectical materialism theory, becomes extensively increased, throughout the world.

• This equation is powerful more than Einstein equation E = MC2, which is used for making Hydrogen, atom and nuclear weapons and used against human civilization and destroying millions of people by Imperialistic countries.

But this equation is powerful by many folds; it frights against imperialistic and their networks multinational drug companies, because their 80% of pharmaceutical products becomes useless, when this equation extended throughout the world; by the properties of prevention and curative of diseases with this equation, millions of people of poor countries will be benefited.
5. This equation helps to meet the goal, that is, health is a issue of social justice (affordable, accessible, assessable by all the people of the world), because it is:-



a. Cost effectiveness, simple method


B.. Teaches to avoid unnecessary effortless expensive and sophisticated tabs and Inj. for only symptomatic treatments of many-many chronic diseases

6. This equation shows the use of philosophy i.e. dialectical materialism and mathematics in the field of health and disease that is more scientific, problem oriented and more practical and economic than previous meta-physical technique and statistical approaches.

7. This equation supports the most scientific philosophy so far, i.e. dialectical materialism. Which is the fundamental and scientific philosophy and which outlooks the universe and its contents in most scientific ways and it is the root science of all the branched sciences, key foundation of Marxism.

8. This equation helps to understand of many diseases and their pathology and management of known diseases as well as the diseases, which are still unknown, in more concise, comprehensive, molecular and atomic as well as quantum level (light reaction).





9. This equation actually establishes the incomplete modern medicine as near complete modern and advanced medicine. Now any body who believe in science and its method, you can have relative complete answer about curability of chronic diseases and prevention which are, before this, not possible and you can have answers for critics (e.g. Para scientific alternative medicine system, e.g. Maharaj Ram Dev of Astha channel, because he himself does not know the mechanism actions of Yoga or any type of anaerobic exercise), and this equation explains the mechanism of anaerobic exercise, i.e. ANTI-STRESS ELEMENT level increased into the cell via decreasing  antistress element ion excretion from the kidney and by decreasing basal metabolic rate ( hence there is increased ATP and ADP level into the cell).

a. Hence for very sick person and for children, who cannot perform anaerobic exercise, what is the alternative drug? The answer is the antistress element Supplementation.

b. Thus this equation gives answer for both practicener like Para scientific alternative practicener (like Maharaj Ram Dev of Astha channel), and practiceners of incomplete modern medicine systems, who cannot treat most of the chronic diseases by their knowledge and practice so far.

10. As it uses the most powerful and scientific philosophy and mathematics, in this equation, in the field of health and disease, which gives more comprehensive and relatively more accurate outcome when it is used in our daily life. It means it gives more reliability and validity to carry out further researches and studies by using this equation and its guideline principle, the dialectical materialism.

11. Hence this equation is a sort of pioneer victory against much acute and chronic medical and surgical diseases by human being, with a cost of minimal expenditure only.

12. This equation is a scientific equation, which organized by unification of conclusion of dialectical materialism, pathogenesis of many diseases, human physiology, and its regulation, role of ANTI-STRESS-ELEMENT in human body in physiological as well as pharmacological level, Role of  mastser element in  bio ecosystem to evolution of protoplanetary disk, pathophysiologic pathways, mediators of many vasculitic diseases and other physical and mental stress conditions, extractions of more than 5000 studies of this master antistress element in human diseases, carried out by many peoples of the world .

13. This equation supports the concept of one drug for all mugs or diseases, which is a completely new concept in modern medicine. This concept is being raised from other fields of medicine e.g gene therapy,TNF-alpha inhibitors(but they are immunosuppressants), stem cell implantation technique, UV and low level laser therapy, universal immunization technique via anaerobic exercise, these are some models of one drugs for all mugs/ diseases.1st three are very expensive and needs sophisticated instrumentation as well as highly qualified man power and last one is not applied for children and acute severe illness of in adults (limitation is more), Hence more effective, cost effective, easily available drug is  master antistress factor .


14. This equation proves that the dialectical materialism, a major fundamental part of Marxism is not dying out but it is being appeared or arising from every matter, from every system, from society and from every individual, in the form of master elemental matter. Which helps to maintain individual’s immune status and thinking power  and fights against the disease mediator TNF-alpha and the disease vasculitis/ stress factor). This equation serves all the people of this world and teaches to fight against diseases by scientific ways, & helps to stop exploitation from many multinational drug companies throughout the world. This equation is a just as an extreme powerful nuclear weapon against impairlistic countries which holding this beautiful world in their fists. Now onward  this master antistress element fights with multinational drug companies of impairlistic conrtries of world, they will spent their energies just attenuate this extreme powerful equation. But science is science truth is truth no one can stop this objective reality/ facts when all the medical practicener and individuals of this world become awareness about versatility, unique, essential and master drug .



15. This equation helps to explore the controvercies of current medical practices and philosophy., and gives alternatives for correction of these controvercies. Examples of important controvercies :-

a)the definition of health by WHO, is not an objective reality.

uanable to define the disease by WHO officially.

b)use of steroids and immunosupressants in the management of hundreds of acute and chronic diseases imperically.,

c)vigorous researches regarding universal therapy with TNF-alpha inhibitors( e.g.thalidomide,infliximab,etanercept) with immunosupressant effects just for suppression of symptoms of chronic diseases;

d) the uses of anti-retroviral agents in HIV infection and AIDS which causes more mortality and anti –retroviral resistance e.g. flaring up of AIDS in Africa and anti-retroviral drugs resistance, the main cause is the malnutrition rather than strength of HIV.

e)Failure to correlate scientifically with other alternative medical therapies e.g. with meditation/YOGA ,anerobic exercises, Low Level LASER Therapy, Homeopathic principles, and herbal therapy , Naturopathy-Hot spring bath, dead sea therapy.,pranayan and YOG thaerapy.

f)The HIV hypothesis as a sole cause of AIDS so on. .

g)Unable to treat in curative aspects for hundreds of acute and chronic diseases satisfactorily .

h)The prime cause of oncogenic diseases and their curative and preventive management , is still not stablished.

- the prime cause of various psychiatric disorthers are not stablished yet.

16. This equation analyses critically the management practice of present medical system for so many vasculitis diseases, autoimmune diseases , malignancies, rheumatic disease and many acute disease VIZ sepsis, ARDS tetanus etc.

• According to our present medical practice the available drugs are corticosteroids (as Anti-inflammatory & immune suppressants), cyclophosphamide, methotraxate (mostly used immune suppressants) for above-mentioned hundreds of diseases.

• with these drug, we are achieving only suppressing of symptoms of disease but not curative & asserting of progression of pathogenesis.

• with taking lots of risk factors (side effects) by using these drugs, (The development Hx of modern medicine is more than 200 yrs) up to now we are depending on these illusional drugs for treatment of so many diseases in our society. It is not due to any other thing, just due to over looking of dialectical materialism principle, which teaches us to find out new methods, techniques to solve our daily problems.

• The drugs we are using in so many diseases have so many adverse effects, that leads unknowingly or knowingly to the mouth of death to us.

17. This equation helps to review of use of steroids & immune suppressants criticality





a) Disadvantages of

Corticosteroids



The therapeutic indication of corticosteroids if you count you can find more then 200 indication as for above mentoioned various chronic, procurable disease with having sirious numerous adveres effects e.g.

Withdrawal effects

Adrenal insufficiency

Glucocorticoid withdrawal syndrome (fever, myalgia, athralgia, malaise)

Pseudotumor cerebri (increased ICP and papiloedema)

When used superphysiological range.

Fluid and electrolyte imbalance

Hypertension

Hyperglycemia

Increased susceptibility of infection

Osteoporosis

Myopathies

Behavioral disturbance (nervous ness)

Growth arrest in children

Redistribution of fat (cushinoid syndrome)

Risk of reactivation of TB

Cataract, Glaucoma, retinopathy

Osteosclerosis

Osteopenia

Treatment failure (resistance to steroid therapy)

Alteration in mood

Psychosis

Peptic ulcer diathesis

Pancreatitis



(Ref: - Goodman & Gilman’s pharmacological basis of therapeutics, 10th edition, 2003 page 1657-1676; and Harrison’s principle of internal medicine, 16th edition, page, 2013.)

b) Side effects of cyclophosphamide

Bone marrow suppression

Cystitis

Bladder carcinoma

Gastrointestinal intolerance

Hypogammaglobunemia

Pulmonary fibrosis

Oncogenesis



(Ref: - Harrison’s principle of internal medicine 16th edition, page 2013).



c) Side effect of Methotraxate: -

Gastrointestinal intolerance

Stomatitis

Neutropenia / Recurrent infection

Hepatotoxicity (fibrosis/cirrhosis)

Pneumonitis

Teratogenicity

Opportunistic infection



(Ref: - Harrison’s principle of internal medicine, 16th edition, page 2013).



Since, we have no alternative so far, to these anti inflammatory and immune suppressant to many chronic vasculitic, autoimmune, connective tissue and degenerative disease. And we are so help less with these treatment modalities and not satisfying, as it is not a curative management and having lots of side effects with these drugs. It is necessary to find out the patent anti inflammatory as well as immune modulator (not the immune suppressant); and versatile compound, which is not only symptomatic reliever but also curative agent with minimal tolerable side effects with having antidotes for its toxicity.



This possible compound is found out by this equation e.g.





                               
Vasculitis =TNF-alpha / Antistress factor




This versatile antistress factor acts as following ways.



• Potent anti-inflammatory agent

• Potent anticonvulsant

• Potent immunomodulator

• Potent antistress agent

• Potent cytoprotective / Neuroprotective/ vasodilator

• having minimal side effects

• Very cheap and available everywhere, can not be petented

• Having anti dote for it’s over dose .

• Many other important physiological and pharmacological actions.





18.this equation helps to understand the reality of corticosteroids: -



• In the normal physiological condition, if stress is occurred (injuries, infection, mental and physical stresses), there is increased release of cytokines, TNF-alpha, IL-I, IL-6 as well as anti-inflammatory molecules.

• Some time there is increased Glucocorticoid to compensate the inflammatory action of cytokines; by decreasing the production of WBC or increasing the killing of activated T or B lymphocyte and macrophages ultimately there is decrease amount of WBC relatively.

• if stress factor is high in magnitude then the physiologic compensation is distorted, and again there is more production of cytokines relatively high than that of anti-inflammatory molecules, causing symptoms of systemic inflammatory response syndrome (SIRS).

• this means, glucocarticoids, can work in its physiological concentration in very well manner. In this condition body can tolerate the immune status (not so much immune suppression). But in the pharmacological systemic use of glucocarticoids for a long time, it is obviously decreased the inflammation by decreasing by defocusing production of cytokines, leukotriens by decreasing proliferation and activation of over all immune cells. Which leads side-by-side massive immune suppression (also suppression of proliferation and activation of anti inflammatory molecules, antibodies, which fights against microbes, viruses, and many stress factors), causing risk of initiation of many opportunistic infection, flaring of previously existed minor infection sub acute infections and appearance of various side effects. As the stress factor concentration is same which is not attenuated (supposed to be attenuated by anti inflammatory molecules, antibodies). And only there is decrease level of inflammatory molecules, thus when there is stopped this corticosteroid, then there is again reappeared of pervious sign & symptoms of the particular disease e.g. Nephritic syndrome, nephrotic syndrome, connective tissue disorders, autoimmune diseases and so on. Hence glucocarticoids is not a curative agent, and just a symptom masker, which is a very dangerous agent, because, disease pathogenesis is continuously growing up but not disappearance of causative stress factor in the body. Thus, when it is used for a long time, it is not more than a suicidal attempt. Hence the action of corticosteroids is a just not more than illusion, which is not a objective reality in the

• field of curative approach of disease treatment in pharmacological doses.



19.That ‘s why, this R.K Dhaugoda’s general equation of vasculitis, strongly apposes to use of corticosteroid and immune suppressant to manage so many chronic and autoimmune disease just for masking their signs and symptoms only. And using these compounds we are failing to treat these vasculitic, autoimmune, Rheumatic disease ,malignancy so far.





This equation,

 VASCULITIS  = TNF-alpha / Anti-stress-element


( RKDHAUGODA'S GENERAL EQUATION OF VASCULITIS )

Gives an alternative approach to manage the many chronic diseases including type-II DM, HTN, atherosclerosis various form of vasculitic diseases with a versatile, master, and unique properties OF RKDHAUGODA'S ANTISTRESS FACTOR .This is a not only symptomatic but also a curative approach with less side effects, with least cost and world wide accessibility, assessibility, with effective measure.


20. This powerful equation establishes, THE RKDHAUGODA'S ANTISTRESS FACTOR  AS the most powerful weapon for fighting against hundred of incurable chronic disease so far. Hence this master and versatile drug is being arising from third world like Nepal and hight of RKDHAUGODA'S ANTISTRESS FACTOR is equivalent to that of Mount Everest. From the height of  RKDHAUGODA'S ANTISTRESS FACTOR having highest hight as compare to Mt. Everest, We can see all the vasculitis and other chronic disease in concise, comprehensive way, and makes easy to manage these incurable disease so far, so simply with very much cost effectiveness ways. And this equation says that the traditional illusional symptomatic drugs like corticosteroids, methotraxate, and cyclophosphamide in the management of chronic vasculitis disease are going to dying out.



21. This equation says that the indications of glucocorticoids reserve to just its replacement therapy and some local uses only.

And this equation says that, in every indication of steroids, now onward it is better and more scientific or curative approach to use RKDHAUGODA'S ANTISTRESS FACTOR as anti-inflammatory & immune modulator as well as antistress factor.



As to reach to the summit of Mount Everest, it can be possible from the south coal (from Nepal) & North side (Tibet, China). In same way, more easy and cost effective way to treating so many chronic diseases by immune modulator approach via ANTISTRESS FACTOR ELEMENT rather than immune suppression approach via steroids & immune suppressant agents.