SOICHI SAKATA- PHYSICIST
R.K.DHAUGODA’S
By-Dr.Raj Kumar Dhaugoda,MBBS (TU),MD Family Medicine(BPKIHS),
.
Dialectical Materialism and Science
This materialist philosophy is the Dialectical Materialist Philosophy of Science, which the development of sciences in the last one hundred years has shown to be the only satisfactory philosophy of science, capable not only of a, description of the knowable, but also of predicting new objects and phenomena. According to Dialectical Materialism, nature exists externally and independently of our consciousness, and is projected into consciousness through our senses. According to Engles, Nature is by no means an accidental collection of objects and phenomena which are mutually separated, isolated and independent. It consists of one thing that is mutually related, dependent, restrictive and connected The all of nature from the smallest elements to the largest, has its existence, in the eternal coming into being and passing away, in ceaselesflux in unresting motion and change.
The dialectical materialist view of nature described above is not one,, imposed on nature but is the one abstracted out of the latest discoveries of science till about 1870. The discoveries in sciences since then have only confirmed the above dialectical view. It has not contradicted it. Dialectical Materialism insists on the approximate, relative character of every scientific theory of the structure of matter and its properties^ it insists on the absence of absolute boundaries in nature, on the transformation of moving matter from one form into another.
According to the Japanese physicist, Soichi Sakata:
Current science has found that in nature there exist qualitatively different levels'?a series of levels such as elementary particles? atoms molecules?masses?heavenly bodies?nebulae. These levels form various qualitative modes of existence of matter in general.
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He used Marxism creatively in Nepali context, and applied to build a new 21st century’s Marxism in Nepali politics-as PEOPLE’S MULTY PARTY DEMOCRACY.
Bhandari was born in Taplejung. He studied in Varanasi, India and in 1972 was named central committee member of the Janabadi Sanskritik Morcha (Democratic Cultural Front), a student's movement launched by Pushpa Lal Shrestha. Around 1976 he left Pushpa Lal's Communist Party of Nepal to launch the Mukti Morcha Samuha ("Liberation Front Group"), which formed an alliance with the survivors of the Jhapa Movement in 1978. He was a founder member of the Communist Party of Nepal (Marxist-Leninist) preceding the 1980 referendum and was elected general secretary at its fourth national in 1986.
When CPN (ML) merged into Communist Party of Nepal (Unified Marxist-Leninist) in 1991, Bhandari became the general secretary. Bhandari was the engineer behind the programme of CPN (UML), People's Multiparty Democracy, which led his party as the strongest communist party of Nepal for several years even after his death.
In 1993 Bhandari died, supposedly in a car crash without anyone as eye witness. Many believe he was murdered. Among the three passengers inside the car, only the driver Amar Lama survived and two leaders Madan Bhandari and Jeev Raj Ashrit died. The then government formed a probe committee but officially the car crash was reported as an accident without any sign of conspiracy. Possible conspiracy again came into concern after the only survivor of that crash; Driver Amar Lama was murdered after about 10 years by unknown person.
His main contribution to communist movement of world and like Nepal is that he stressed to democritization for peaceful social change , and gaining social achievement and he used Marxism creatively to form peoples’ multi-party democracy. It’s a great theoritical achievement in communist movement of world.
The old concept of communist movement is only basing to war with bullet, which is breaked by him , showing that the organised people of communist party can ballet peacefully rather than forcefully immature so called peoples war( the war , less involement of general people volunteerly, low level of awarness and without feasible circumstances) .
In context of Nepal ,the 10 years MAOIST’S peoples war ( around 15000 people were killed ) is lastly converted into 19th days successful peaceful movement of -2005-2006 ,held collaboration of various seven partieis including NEPALI CONGRASS, CPN (UML) ,CPN ( MAOIST ) and various 4 parties ( only around 25 people were killed ), which helps to establish Nepal as republic ( this is a sort of wining power of peaceful movemnts of communist parties with collaboration of democratic forces against feudalistic-Monarchism .).
THE MAOIST PRESIDENT PRACHANDA HAS ALSO THANKED TO MADAN BHANDARI’S IDEA THAT IS PEACEFULL PEOPLES GENERALISED MOVEMENT IS MORE POWERFUL AND LEGALISED THAN ANY SORT OF POWERFUL ARMED WAR.THIS IS ALSO A BITTER TRUTH FOR MAOIST OF NEPAL, AND THERE ARE EXERCISING THEIR WAY TO GO WITH EITHER COSEVATIVELY OR IN THE WAY OF PEOPLE’S MULTIPARTY DEMOCRACY FOR LIGELISED SOCIAL CHANGE GRAGUALLY RATHER THAN FORCEFULLY.THE MAOIST OF NEPAL HAS REACHED TO ABLE TO FORM GOVERNMENT ACTUALLY DUE TO BALLET with some thing triky THE YCL SEMI-ARMED YOUTH LEAGE NOT DUE TO DIRECT BULLET FORWARDING TO NEPAL ARMY.
THE MAIN FEATURES OF MADAN BHANDARI’S PEOPLE’S MULTI –PARTY DEMOCRACY CONCEPT ARE-
1. He is an upholder of the principles of socialism and pursues the road of People's Multi-Party Democracy, which is a creative application of Marxism and Leninism in the Nepalese condition.
2. Consolidation of democracy, strengthening people's sovereign rights, changing the socio-economic relation and acceleration of the economic development in the country are the major concerns of the Party.
3. Periodical election and the government of the majority, pluralism, rule of law, human rights are other important elements of the People's Multi-Party Democracy.
4. Economically self sustained society, quality education and health service, full employment and social security are important features of the Party program aiming to achieve the welfare state.
5. The Party fully believes in the harmony and the unity among the people of all religions, castes, communities and ethnic groups living in different geographical regions of the country.
6. The Party works against any discrimination based on race, religion, caste, ethnicity, sex and geographical region.
7. It restricts any sort of class over sensation e.g. racial conflicts/ religious conflicts( it restricts any racial or religious federalism in the country ). Should stop any sort of class over sensation, which leads any social and national conflict unnecessarily.Maoists of Nepal ,are anti- communist – because – believing in any sort of racial federalism in the country is unscientific to any communist party ).
8. The world is in a age of generalization or globalization,so talking about racial fedaralism is just going back to 15TH century’s isolated society .21st century is the age of mobilization, immigration ,massive-integration of people ,socially,technically,economically, linguelly,and culturally.Every thing will be mutual integrated and hybrided.world is being so narrow and try to divid or isolate a nation to in many slices is unscientific .Racial federalism helps to weak socialization and democratization in the nation.The cause of collapse of former USSR is just due to class over sensation(the slogan of racial liberation ) after 1990.
He believes that the material development of society should be closely linked with the spiritual enlistment of the people and it should be guided by the ideals of democracy and socialism.
DR. RAJ KUMAR DHAUGODA.
General Theory of Vasculitis
A SPECIAL RECENT ADVANCES IN MODERN MEDICINE
A creative application of DIALECTICS ( MARXIST PHILOSOPHY) , IN MEDICAL SCIENCE.
By-Dr.Raj Kumar Dhaugoda,MBBS (TU),MD Family Medicine(BPKIHS),Nepal
(MEDICAL SCIENTIST AND MARXIST PHILOSOPHER)
From the various conclusions of various literature reviews, discussions, and various studies and findings, which are presented previous chapters( THE BOOK - RKDHAUGODA'S GENERAL THEORY OF VASCULITIS -PART-I). It is hypothesized to build the general theory of vasculitis, with the help of guide line theory that is dialectical materialism, to express the objective reality of the physiological and pathological laws within the human body and to solve many problems in the field of management of health and disease in the huge proportional of population, in terms of effective, preventive, curative with least costs and simple techniques and coordinating with other various scientific approaches. According to this theory:
(1) Any inflammatory (infectious or non infectious & endogenous or exogenous originated disease is associated with varying degree of vaculitis in relation to time, space, motion and matter (antigen specific/strss factors/antistress factors). It means the main / key pathology of any inflammation is the vaculits (primary or secondary vaculitis). Vaculitis is the inflammation of vascular system,and associated with inflammation of any types of cells of the body. The vascular system in human body is widely and extensively distributed (except hair, nail and cornea). The vascular system e.g. micro vessels namely capillaries, sinusoids, venules are connected with every cells of the body by means extra cellular fluids. Hence any tissue or cell damage is associated with vascular abnormalities.
(2) All the inflammatory originated diseases having the common pathology vasculitis are principally mediated by the major factor TNF- alpha). It means TNF- alpha is the principle cytokine, and principle pathogenic mediator for all types’ vasculitis diseases (from boils to cancer pathology).
(3) All these vasculitis pathology have relatively high level of TNF- alpha in the circulation, which are associated with relative hypo- ANTI-STRESS ELEMENT). Because in any hypo- ANTI-STRESS ELEMENT condition, there is increased synthesis of TNF- alpha and they’re appearance of inflammatory response, and then various degree of vasculitis process is developed.
(1) Any inflammatory (infectious or non infectious & endogenous or exogenous originated disease is associated with varying degree of vaculitis in relation to time, space, motion and matter (antigen specific/strss factors/antistress factors). It means the main / key pathology of any inflammation is the vaculits (primary or secondary vaculitis). Vaculitis is the inflammation of vascular system,and associated with inflammation of any types of cells of the body. The vascular system in human body is widely and extensively distributed (except hair, nail and cornea). The vascular system e.g. micro vessels namely capillaries, sinusoids, venules are connected with every cells of the body by means extra cellular fluids. Hence any tissue or cell damage is associated with vascular abnormalities.
(2) All the inflammatory originated diseases having the common pathology vasculitis are principally mediated by the major factor TNF- alpha). It means TNF- alpha is the principle cytokine, and principle pathogenic mediator for all types’ vasculitis diseases (from boils to cancer pathology).
(3) All these vasculitis pathology have relatively high level of TNF- alpha in the circulation, which are associated with relative hypo- ANTI-STRESS ELEMENT). Because in any hypo- ANTI-STRESS ELEMENT condition, there is increased synthesis of TNF- alpha and they’re appearance of inflammatory response, and then various degree of vasculitis process is developed.
(4) These relations of vasculitis, TNF- alpha and relative level of intracellular ANTI-STRESS ELEMENT, remains in functional state, when there remains constant i.e. the possibility of reversion of pathogenesis of involved organ. This functional limitation of reversibility of pathogenesis is represented by the R.K.Dhaugoda’s. constant equals to 1, this value remains constant up to before irreversibility damaged of organic function (e.g. chronic renal failure, chronic liver failure, brain death, chronic brain damage /severe encephalopathy).
(5) All these disease, which is associated with vasculitis pathology, are treated with pharmocotherapy of ANTI-STRESS ELEMENT principally, and with adjunctive therapeutic tools, antimicrobials, antiviral, antifungal, antiparasitic, and other various supporting drugs and techniques viz biomechanical (surgical/mechanical ventilation) until stabilization of severe disease pathology, and clinical stability. Then oral ANTI-STRESS ELEMENT is given for chronic and long-term preventive as well as curative management of various incurable diseases are treated with various integrated ways (to maintain the optimum level of intracellular ANTI-STRESS ELEMENT relatively), e.g.(a) By increasing education level of individual/ society regarding scientific understanding of disease process, causation, intervention, complications, prevention, and ways of scientific management, and the biological, physiological role of ANTI-STRESS ELEMENT and its importance via increasing the knowledge and practice of dialectical materialism thought and principles, broadly throughout the world. Because this dialectical materialistic view is the core/root science for all the remaining branched sciences. Without its knowledge, we can’t understand the laws of universe and its contents scientifically.(b) By modifying nutrition, lifestyle and behaviors (being anti sadists to ownself and to others). Viz taking, low fat diet, low sugar diet, moderate physical exercise, relatively high ANTI-STRESS ELEMENT containing diets avoiding smoking, alcohol, excess tea, coffee, sodium, azinomotto ( mono-sodium-glutamate), and avoiding excessive worry ness and anxiety these all positive activities cause increased intracellular ANTI-STRESS ELEMENT relatively.(c) Practicing various types of physical exercises:-anaerobic exercise, yoga,pranayam .
(5) All these disease, which is associated with vasculitis pathology, are treated with pharmocotherapy of ANTI-STRESS ELEMENT principally, and with adjunctive therapeutic tools, antimicrobials, antiviral, antifungal, antiparasitic, and other various supporting drugs and techniques viz biomechanical (surgical/mechanical ventilation) until stabilization of severe disease pathology, and clinical stability. Then oral ANTI-STRESS ELEMENT is given for chronic and long-term preventive as well as curative management of various incurable diseases are treated with various integrated ways (to maintain the optimum level of intracellular ANTI-STRESS ELEMENT relatively), e.g.(a) By increasing education level of individual/ society regarding scientific understanding of disease process, causation, intervention, complications, prevention, and ways of scientific management, and the biological, physiological role of ANTI-STRESS ELEMENT and its importance via increasing the knowledge and practice of dialectical materialism thought and principles, broadly throughout the world. Because this dialectical materialistic view is the core/root science for all the remaining branched sciences. Without its knowledge, we can’t understand the laws of universe and its contents scientifically.(b) By modifying nutrition, lifestyle and behaviors (being anti sadists to ownself and to others). Viz taking, low fat diet, low sugar diet, moderate physical exercise, relatively high ANTI-STRESS ELEMENT containing diets avoiding smoking, alcohol, excess tea, coffee, sodium, azinomotto ( mono-sodium-glutamate), and avoiding excessive worry ness and anxiety these all positive activities cause increased intracellular ANTI-STRESS ELEMENT relatively.(c) Practicing various types of physical exercises:-anaerobic exercise, yoga,pranayam .
(6) In this theory, it is estimated even sub clinical stage of diseases or pre-estimation of relative risk of diseases. By means measuring the relative level of the C- reactive protein (a functional biological marker of hypo-ANTI-STRESS ELEMENT, inflammation in the body, and the level of cytokine e.g., TNF- alpha in the circulation). It says that even a person with relatively non-significant clinical disease, by measuring of C-RP level, if it is relatively high comparing to normal value, it is predicted the various risk for various diseases, specially Chronic diseases. A person having Type -2 DM, arteriosclerosis, vascular diseases and with high C-RP level has more risk for cardiovascular diseases e.g., Heart attack, Angina, Ischemic heart disease, CRF and stroke etc.
(7) In this theory, it is applied the dialectical materialism principle which is the root science for all the branched sciences. The pathology of any disease is represented relatively & commonly by vasculitis. The intracellular relative level of ANTI-STRESS ELEMENT represents body’s physiological status (immune status), Vasculitis and magnitude of Intracellular ANTI-STRESS ELEMENT (immune status) are opposite phenomena in the human body but not isolated from each other, but interdependent and interrelated each other by the relative level of TNF- alpha and C-reactive protein or stress factor in the circulation.In the physiological level range there is relatively less stress factors and less level of TNF- alpha and C- reactive protein (very low level is dominated by bodies immune status) and not causing disease. But when there is relative low level of intracellular ANTI-STRESS ELEMENT. Relative hypo-ANTI-STRESS ELEMENT in comparison to stress factors. It is started to synthesis and activations of TNF- alpha and starts inflammatory response by the body causing various degree of tissue / cell injury. Causing pathogenesis of vasculitis, and synthesis of C-RP in the liver is increased in response to inflammation in the body, overall causing increased level of TNF- alpha, C-RP and appearance of various degree of vasculitis, (Sub clinical to clinical stages). Hence, here the two opposite phenomena immune status (optimum level of intracellular ANTI-STRESS ELEMENT) and disease process / Inflammation (vasculitis) is connected in terms of TNF- alpha and C-RP and stress factors.
(8) In this theory, it is correlated the level of intracellular ANTI-STRESS ELEMENT, TNF- alpha, and degree of various vasculitis, by blood circulation level of C-reactive protein. In practice, it is very difficult to measure sub clinical & clinical vasculitis, like wise the TNF- alpha level and intracellular ANTI-STRESS ELEMENT level very difficult, needs sophisticated instruments, highly qualified man power and excessive costly. But here it is correlated by the level of C-RP with the level of other three parameters e.g. severity of vasculitis, level of TNF- alpha and intracellular ANTI-STRESS ELEMENT level. When there is increased value of C-RP there should be relative hypo-ANTI-STRESS ELEMENT, increased level of TNF- alpha and various degree of sub clinical to clinical form of vasculitis. In absence of other interfering factors for C-RP level in the body e.g. use of Steroids, NSAIDS, Vigorous exercise, excessive Coffee / tea, Hormone replacement therapy, Intra-Uterine device, Pregnancy, use of Statin etc.
(9) highly sensitive C-RP is non-specific biological marker of inflammation and body stress, raised its value in various types of Inflammations and exposure to stress factor by the body systems.
(7) In this theory, it is applied the dialectical materialism principle which is the root science for all the branched sciences. The pathology of any disease is represented relatively & commonly by vasculitis. The intracellular relative level of ANTI-STRESS ELEMENT represents body’s physiological status (immune status), Vasculitis and magnitude of Intracellular ANTI-STRESS ELEMENT (immune status) are opposite phenomena in the human body but not isolated from each other, but interdependent and interrelated each other by the relative level of TNF- alpha and C-reactive protein or stress factor in the circulation.In the physiological level range there is relatively less stress factors and less level of TNF- alpha and C- reactive protein (very low level is dominated by bodies immune status) and not causing disease. But when there is relative low level of intracellular ANTI-STRESS ELEMENT. Relative hypo-ANTI-STRESS ELEMENT in comparison to stress factors. It is started to synthesis and activations of TNF- alpha and starts inflammatory response by the body causing various degree of tissue / cell injury. Causing pathogenesis of vasculitis, and synthesis of C-RP in the liver is increased in response to inflammation in the body, overall causing increased level of TNF- alpha, C-RP and appearance of various degree of vasculitis, (Sub clinical to clinical stages). Hence, here the two opposite phenomena immune status (optimum level of intracellular ANTI-STRESS ELEMENT) and disease process / Inflammation (vasculitis) is connected in terms of TNF- alpha and C-RP and stress factors.
(8) In this theory, it is correlated the level of intracellular ANTI-STRESS ELEMENT, TNF- alpha, and degree of various vasculitis, by blood circulation level of C-reactive protein. In practice, it is very difficult to measure sub clinical & clinical vasculitis, like wise the TNF- alpha level and intracellular ANTI-STRESS ELEMENT level very difficult, needs sophisticated instruments, highly qualified man power and excessive costly. But here it is correlated by the level of C-RP with the level of other three parameters e.g. severity of vasculitis, level of TNF- alpha and intracellular ANTI-STRESS ELEMENT level. When there is increased value of C-RP there should be relative hypo-ANTI-STRESS ELEMENT, increased level of TNF- alpha and various degree of sub clinical to clinical form of vasculitis. In absence of other interfering factors for C-RP level in the body e.g. use of Steroids, NSAIDS, Vigorous exercise, excessive Coffee / tea, Hormone replacement therapy, Intra-Uterine device, Pregnancy, use of Statin etc.
(9) highly sensitive C-RP is non-specific biological marker of inflammation and body stress, raised its value in various types of Inflammations and exposure to stress factor by the body systems.
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